SynAbs S.A. Driving mab innovation for the IVD & BioPharma R&D markets
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1 SynAbs S.A. Driving mab innovation for the IVD & BioPharma R&D markets February 20, 2016
2 SynAbs in a nutshell (1/2) Rat monoclonal antibodies, service and catalog Innovative guinea pig monoclonals! Mouse monoclonals and rabbit polyclonals A team with a strong immunology background From ascites to In Vitro Production expertise The one-stop-shop solution for your mab project : Antigen synthesis, hapten-carriers chemistry Parallel Immunisation : rat and/or mouse and/or guinea pig. Clone selection & delivery Custom manufacturing from mgr to gr level Full biotech support by RD-Biotech and Diaclone.
3 SynAbs in a nutshell (2/2) Spin-off UCL/CHEX Location : Brussels area Team : 7 scientists Board : RD-Biotech/Diaclone, UCL, WBC. Funding : 400k Revenues : 500k, consistently growing.
4 General overview of the SynAbs Offer A large catalog, distributed by worldwide leaders ~100 mabs (rat & mice) antibodies : Secondary mabs : Anti -mice, -rat & -human Ig isotyping, sandwich ELISA, WB, FACS, IHC, IgG Isotype controls : rat anti-mouse, mouse anti-rat, rat anti-human Irrelevant Ig and control Ig such as anti-dnp Anti-cytokines Custom services: from antigen synthesis to mabs generation Multi-species immunisation for a competitive price maximizes the success rate R&D Partnership, added value for codevelopment program
5 Why using rat for mab development? Used for murine antigens Excellent for small molecules (antibiotics, toxins, ) Host variation offers different antibody responses Access to the lymph nodes, larger spleen yield No special growth media required Pair with existing mouse antibodies in sandwich assays Multiple labelling possibility Stable and productive rat-rat hybridomas thanks to our proprietary rat (x rat) fusion cell line (myeloma).
6 Some rat case studies Successful mabs development against steroïd and antibiotics Development of IgE anti-dnp Development of S. aureus diagnostic kit (MRSA/VRSA) mab anti-protein A with no cross binding with rat Fc mab anti-fluorescein isothiocyanate A whole rat mab anti-isotype (mouse and human)
7 SynAbs, Custom Services Value proposition and differentiation Proprietary guinea pig fusion cell line (myeloma) mab development against murine antigens Non-murine immune repertoire (outbreed) Unique model for therapeutic development : Distinctive immune response
8 Why using guinea pig? If the target protein is highly conserved between mice/rat/rabbit/human If the target protein can be recognized as self-antigen by mice If glycemic hormones are an issue (insulin,glucagon,..) For therapeutic development in Ebola, Marburg, HSV, Tuberculosis, Legionella, Chlamydia, Osteoarthritis,
9 Monoclonals against human antigens CNS : Anti zeta: neurodegenerative disease marker Anti GLT1 a et B (glutamate receptor, mouse astrocytes) Transplant rejection : Anti CD2 (LO-CD2 Siplizumab) & Anti CD25 (LO-Tact) (Siplizumab) Miscellaneous : Anti human J chain (IgA) Anti PRDX 5 (peroxyredoxin)
10 Miscellaneous, Vet & Infectious diseases Pig : Anti IgM, anti IgG, anti Kappa Horse : Anti IgG Chicken : Anti IgY Dog : Anti Ig Infectious diseases : Anti PA, antrax Anti Vaccine-variole Anti Protein A, S. aureus
11 Why SynAbs? Recognized expertise : H. Bazin work Optimized and efficient protocols for immunizing rats, fusions, screening hybridomas, and delivering hybridoma (cell lines) Customizable offer at any step Full service integration : whole set of services for initial antigen preparation, subsequent antibody production and purification Alternatives to mouse model at affordable costs to increase the success of your projects
12 They trust us
13 CONTACTS Mabs catalog : nisolf@synabs.be bollef@synabs.be Custom Mabs generation Services : argentind@synabs.be isoard@synabs.be nizety@synabs.be Corporate : argentind@synabs.be
14 (1) Catalog, Mice mabs anti-rats & DNP Antibody Code Antibody Name Host Species MARK-1/3 Anti-rat kappa 1a + 1b light chain Mouse MARL-15 Anti-rat lambda light chain Mouse MAR(K+L) Anti-rat lambda and kappa light chains Mouse MARM-4/7 Anti-rat mu heavy chain Mouse MARD-3 Anti-rat delta heavy chain Mouse MARA-1/2 Anti-rat alpha heavy chain Mouse MARE-1 Anti-rat epsilon heavy chain Mouse MARG1-1/2/5 Anti-rat gamma 1 heavy chain Mouse MARG2a-1/7 Anti-rat gamma 2a heavy chain Mouse MARG2b-3/8 Anti-rat gamma 2b heavy chain Mouse MARG2c-3/5 Anti-rat gamma 2c heavy chain Mouse MARGCOC-1/3 Anti-rat total IgG heavy chain Mouse MADNP-1/2/3/4/5 IgG1 kappa anti-dnp Mouse
15 (2) Catalog, Rat mabs, Anti-mice, rat, human, rabbit, DNP Antibody Code Antibody Name Host Species LO-MK-1/2/3 Anti-mouse kappa light chain Rat LO-MM-3/8/9 Anti-mouse mu heavy chain Rat LO-MA-7/10 Anti-mouse alpha heavy chain Rat LO-MD-6/8 Anti-mouse delta heavy chain Rat LO-ME-2/3 Anti-mouse epsilon heavy chain Rat LO-MG1-2/13/15 Anti-mouse gamma 1 heavy chain Rat LO-MG2a-2/3/7/9 Anti-mouse gamma 2a heavy chain Rat LO-MG2b-1/2 Anti-mouse gamma 2b heavy chain Rat LO-MG3-7/13 Anti-mouse gamma 3 heavy chain Rat LO-MGCOC-2 Anti-mouse total IgG heavy chain Rat LO-RK1b-1/2 Anti-rat kappa 1b light chain Rat kappa 1a IR202/473 IgM kappa myeloma Rat IR22/1060 IgA kappa myeloma Rat IR2/162 IgE kappa myeloma Rat IR595/871/27 IgG1 kappa myeloma Rat IR31 IgG1 lambda myeloma Rat IR418/452 IgG2a kappa myeloma Rat IR863 IgG2b kappa myeloma Rat IR304/1148 IgG2c kappa myeloma Rat LO-hK-3 Anti-human kappa light chain Rat LO-HhL-2 Anti-human lambda light chain Rat LO-hM-2/7/18 Anti-human mu heavy chain Rat LO-hD-11 Anti-human delta heavy chain Rat LO-hE-10/17 Anti-human epsilon heavy chain Rat LO-hA-8 Anti-human alpha 1 heavy chain Rat LO-hA-9 Anti-human alpha 1+2 heavy chain Rat LO-hG-20/22/24 Anti-human gamma heavy chain Rat LO-FLUO-1 Anti-fluorescein isothiocyanate Rat LO-DNP-34/40 IgM kappa anti-dnp Rat LO-DNP-1/2 IgG1 kappa anti-dnp Rat LO-DNP-16/61 IgG2a kappa anti-dnp Rat LO-DNP-11/57 IgG2b kappa anti-dnp Rat LO-DNP-30/10 IgE kappa anti-dnp Rat LO-DNP-45/64 IgA kappa anti-dnp Rat LO-RG1 Anti-rabbit gamma heavy chain Rat
16 (3) On request, mabs rat/mice Antibody Code Antibody Name Host Species LO-CD2a Anti-human CD2 Rat LO-CD2b Anti-human and baboon CD2 Rat LO-BM-2 Anti-human and baboon IgM Rat LO-Tact-1 Anti-human CD25 Rat FYN6 Anti-GLT 1a+b (glutamate transporter) Rat FYN15 Anti zeta Rat 5C9 Anti-pig IgM Rat F4383H7 Anti-pig IgG Rat LO-GLT1-a anti-human GLT1a receptor Rat LO-GLT1-b anti-human GLT1b receptor Rat LO zeta anti -human Rat MA-PRDX5 anti-human prdx5 Mouse LO-PMA-P anti-phosphorylated ATPase 2 and 4 of Nicotiana tabacum Rat LO-IgY anti-chicken Ig Rat LO-BaPa anti-protective antigen of Bacillus Anthracis Rat LO-A56R anti-a56r of smallpox and cowpox virus Rat LO-ProtA anti-proteina ( does not bind not specifically prot A) Rat LO-PIGk anti-pig Ig Rat LO-PIGg anti-pig IgG Rat MA-HOIgGc anti-horse Ig Mouse LO-DOG anti-dog Ig Rat LO-HJ anti-human J chain of IgA Rat LO-hSC anti-human secretary componant Rat LO-HIL-1 anti-human IL-1 Rat LO-hTNFa anti-human TNFa Rat LO-HLA-1 anti-hla class I Rat
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