2016 Curriculum vitae

Transcription

1 2016 Curriculum vitae Education NAME: David M. Soderlund DEPARTMENT/UNIT: Entomology TITLE: Professor of Insecticide Toxicology Director, Northeast Region IR-4 Program CAMPUS ADDRESS: 4138 Comstock Hall PHONE: B.S.: Ph.D.: Biology (magna cum laude) Pacific Lutheran University, Tacoma, WA, 1971 Entomology (Insecticide Toxicology) University of California, Berkeley, CA, 1976 Positions Held: Postdoctoral Research Fellow, Insecticides and Fungicides Department, Rothamsted Experimental Station, Harpenden, U.K Assistant Professor, Department of Entomology, Cornell University, New York State Agricultural Experiment Station, Geneva, NY Associate Professor, Department of Entomology, Cornell University, New York State Agricultural Experiment Station, Geneva, NY Professor, Department of Entomology, Cornell University, New York State Agricultural Experiment Station, Geneva, NY. Administrative Assignments: Director of the Northeast Region IR-4 Program, Cornell University, New York State Agricultural Experiment Station, Geneva, NY Chair, Department of Entomology, New York State Agricultural Experiment Station, Cornell University, Geneva, NY Associate Chair, Department of Entomology, Cornell University, Ithaca and Geneva, NY.

2 Field of Specialization Biochemical and molecular toxicology of insecticides: neuropharmacology of insecticide action; molecular biology of insecticide target sites; mechanisms of selective toxicity and resistance; biochemistry of detoxication. Honors, Awards, Fellowships National Merit Scholarship, National Institute of Environmental Health Sciences Predoctoral Traineeship, Rockefeller Foundation Postdoctoral Fellowship, Cornell University Travelling Fellowship, 1979 Fulbright Grant-in-Aid, 1990 (declined) Pacific Lutheran University Centennial Alumnus, 1990 Entomological Society of America Eastern Branch Distinguished Achievement Award in Insect Physiology, Biochemistry and Toxicology, 2001 International Award for Research in Agrochemicals, American Chemical Society, Agrochemical Division, 2008 Paul A. Dahm Memorial Lecturer in Entomology, Iowa State University, 2009 Fellow of the Entomological Society of America, 2015 Professional Society Affiliations American Chemical Society Entomological Society of America Teaching Entomology 4900: Insect Toxicology and Insecticide Chemistry (lectures on pyrethroid chemistry and structure-activity relationships, hydrolytic detoxication, and mechanisms of action, ) Entomology/Toxicology 3070: Pesticides, the Environment, and Human Health (full responsibility, , 1985; lectures on pesticide regulation, 2010, 2012, 2014) Toxicology 6100: Introductory Chemical and Environmental Toxicology (lectures on insecticides as chemicals of environmental concern, ; full responsibility ) Toxicology 6110: Molecular Toxicology (lectures on neurotoxicology, , 1999) Entomology 7100: Mastering the Craft of Scientific Writing (full responsibility ) Undergraduate Research Students Adam M. Stuart (independent research; High Honors in Biology, Hobart College, Geneva, NY, 1986) "Neurotoxicity Problems in Mice and Fish: The Sodium Channel as the Primary Target Site of Pyrethroids" Robin E. Grubs (independent research; High Honors in Biology, William Smith College, Geneva, NY, 1987) "The Voltage-Sensitive Sodium Channel of Drosophila: Characterization of the Batrachotoxin Receptor Site" Colleen A. Malay (independent research; Honors in Biology, William Smith College, Geneva, NY, 1992) "The Inhibition of Amino Acid Uptake by Bacillus thuringiensis Toxins in Trichoplusia ni"

3 William Agnew-Svoboda (NYSAES Summer Scholar from Willamette University, Salem OR, 2012) Adapting a bioluminescence-based assay to assess sodium-dependent cytotoxicity in human embryonic kidney (HEK293) cells engineered to express voltagegated sodium channels Graduate Field Affiliations Graduate Field of Entomology, 1980-present Graduate Field of Environmental Toxicology, 1981-present Graduate Students Anuar Morales (minor advisor; M.S. in Entomology, 2008) "Variation in the Susceptibility of Turf-Infesting White Grubs to Different Control Agents and Opportunities for Synergistic Combinations of Biologicals and Neonicotinoids" Richard T. von Stein (major advisor; Ph.D. in Environmental Toxicology, 2011) "Action of Sodium Channel Blocking Insecticides on Mammalian Voltage-Gated Sodium Channels" Xiaozhao Song (minor advisor; Ph.D. in Entomology, 2015) "Resistance to Bacillus thuringiensis Toxin Cry2Ab in the Cabbage Looper, Trichoplusia ni" Liuqi Gu (minor advisor; Ph.D. in Entomology, 2015) "Analysis Of Dosage Compensation Of The Neo-Z Sex Chromosome In The Codling Moth, Cydia Pomonella (Lepidoptera:Tortricidae)" Zachary Cohen (minor advisor; non-thesis M.S. in Entomology, 2016) Postdoctoral Associates and Visiting Scientists Jianguo Tan ( ) Bingjun He ( ) Samantha McCavera ( ) Rubia A. Araujo ( ) Service: University, College and Department Cornell University Radiation Safety Committee, Faculty Advisory Committee for the Cornell Agriculture and Food Technology Park at Geneva, CALS Faculty Financial Advisory Committee, Cornell University Internal Life Sciences Advisory Council, Chair, Cornell Institutional Biosafety Committee, CALS Strategic Advisory Committee, Chair, CALS ad hoc promotion and tenure committees (3) Chair of Entomology faculty search committees (2) Mentoring committees for non-tenured faculty (4 total; chair of 2) Department of Entomology awards committee, 2014-present Service: Professional Societies American Chemical Society Division of Agrochemicals Program Planning Committee, present Co-organizer, American Chemical Society Agrochemical Division symposium on Mechanisms of Insecticidal Action and Resistance: New Compounds and Recent Advances, 2012 Co-organizer, American Chemical Society Agrochemical Division symposium on Insecticide

4 Action on Ion Channels: A Tribute to Prof. Toshio Narahashi, 2015 Service: Editorial Boards Editorial Board Member, Pesticide Biochemistry and Physiology, 1987-present Editorial Board Member, Archives of Insect Biochemistry and Physiology, 1991-present Associate Editor, Invertebrate Neurobiology, Co-Editor, Special Issue of Pesticide Biochemistry and Physiology (Advances in Vector and Urban Pest Management and Resistance), 2013 Guest Editor, Special Issue of NeuroToxicology in honor of Toshio Narahashi (Ion Channels in Pain, Pleasure, Death and Disease: Electrophysiology in the Study of Drugs, Toxins and Insecticides), 2016 Service: Grant Review Panels Invited reviewer, National Institutes of Health Vector Biology study section, 2009 Invited reviewer, National Institutes of Health Neurotoxicology and Alcohol Study Section, 2010 Special review panel, Foundation for the National Institutes of Health/Bill and Melinda Gates Foundation New Insecticides for Malaria Control Program, 2011 Member, National Institutes of Health Neurotoxicology and Alcohol Study Section, Service: Other Peer Reviewing Activities Manuscript reviews for: Aquatic Toxicology, American Chemical Society Symposium Series, Annals of the Entomological Society of America, Archives of Insect Biochemistry and Physiology, Biochemical Journal, Biotechniques, British Journal of Pharmacology, Comparative Biochemistry and Physiology, Environmental Health Perspectives, Epilepsy, Insect Biochemistry and Molecular Biology, Insect Molecular Biology, Invertebrate Neuroscience, Journal of Agricultural and Food Chemistry, Journal of Economic Entomology, Journal of Experimental Biology, Journal of Insect Physiology, Journal of Medical Entomology, Journal of Pharmacology and Experimental Therapeutics, Journal of Physiology, Life Sciences, Medical and Veterinary Entomology, Molecular Pharmacology, Neuroscience Letters, Neurotoxicology, Neurotoxicology and Teratology, Pest Management Science, Pesticide Biochemistry and Physiology, Pesticide Science, PLoS Neglected Tropical Diseases, PLoS ONE, Proceedings of the National Academy of Sciences (USA), Science, Science of the Total Environment, Trends in Neurosciences, Toxicological Sciences Grant proposal reviews for: United States-Israel Binational Agricultural Research and Development Fund, Biotechnology and Biological Sciences Research Council (UK), National Science Foundation, USDA/CSRS National Research Initiative Competitive Grants Program, United States Environmental Protection Agency Service: Other Professional Activities National Research Support Project NRSP-4 ("IR-4 Project," Minor Crop Pest Management) Project Management Committee, 1999-present; Chair,

5 Consultancies Consultant in pyrethroid toxicology, Pyrethroid Working Group, Consultant in the discovery of novel antiparasitic agents, Intervet Innovation GmbH, Schwabenheim, Germany, Consultant in insecticide toxicology, Love & Erskine LLP, Los Angeles, CA, Invited Symposium and Conference Presentations "Insecticide Discovery in the 'Post-Genomic' Era," ACS Agrochemicals Division symposium on The Future Role of Pesticides in Agriculture, San Francisco, CA 2006 "Pyrethroid Neurotoxicity and Effects on Ion Channels," plenary lecture, Pyrethroid Working Group International Workshop on Mechanisms of Pyrethroid Toxicity, Research Triangle Park, NC, 2006 "Pyrethroids, Knockdown Resistance, and Sodium Channels," ACS Agrochemicals Division International Award for Research in Agrochemicals symposium in honor of G. T. Brooks, Chicago, IL, 2007 "State-Dependent Actions of Pyrethroid Insecticides on Voltage-Gated Sodium Channels," award recipient lecture, ACS Agrochemicals Division International Award for Research in Agrochemicals, Philadelphia, PA, 2008 "Mechanisms of Pyrethroid Selectivity," ACS Agrochemicals Division symposium and celebration in honor of Professor John Casida, San Francisco, CA, 2010 Pyrethroid Actions on Sodium Channels: Isoform and Species Selectivity, ACS Agrochemicals Division symposium on Parameters for Pesticide QSAR and PBPK/PD Models for Human Risk Assessment, Denver, CO 2011 Sodium Channel Inhibitor Insecticides: Blurring the Line Between Insecticides and Drugs, ACS Agrochemicals Division symposium on Mechanisms of Insecticidal Action and Resistance: New Compounds and Recent Advances, Philadelphia, PA 2012 "Ion Channels as Insecticide Targets," ACS Agrochemicals Division symposium on Insecticide Action on Ion Channels: A Tribute to Prof. Toshio Narahashi, Boston, MA, 2015 "Functional Reconstitution of Sodium Channels In Vitro for Studies of Insecticide Action," ACS Agrochemicals Division symposium on Insecticide Action on Ion Channels: A Tribute to Prof. Toshio Narahashi, Boston, MA, 2015 Targeting voltage-gated sodium channels for insect control: past, present and future, ACS Agrochemicals Division International Award for Research in Agrochemicals symposium in honor of Y. Ozoe, Philadelphia, PA, 2016 Other Invited Seminars and Lectures 2008: Environmental and Occupational Health Sciences Institute, Rutgers University, New Brunswick, NJ 2009: Department of Entomology, Iowa State University, Ames, IA Department of Entomology, Texas A&M University, College Station, TX 2011: Department of Entomology, Cornell University, Ithaca, NY Department of Entomology, University of Florida, Gainesville, FL

6 SUMMARY OF GRANT SUPPORT Current support USDA ( ): Northeast Region Center for the IR-4 Minor Crop Pest Management Program; Principal Investigator; $825,053; 7/15/14-7/14/16. USDA ( ): Northeast Region Center for the IR-4 Minor Crop Pest Management Program; Principal Investigator; $946,604; 8/15/13-8/14/16. Previous support USDA ( ): Northeast Region Center for the IR-4 Minor Crop Pest Management Program; Principal Investigator; $939,745; 8/1/12-7/31/14. USDA ( ): Northeast Region Center for the IR-4 Minor Crop Pest Management Program; Principal Investigator; $945,840; 8/1/11-7/31/14. NIH (ES013686): Molecular Determinants of Pyrethroid Neurotoxicity; Principal Investigator; $1,324,951; 4/1/07-1/31/13. NIH (ES014591): Insecticide Action at the Local Anesthetic Receptor; Principal Investigator; $1,192,109; 12/1/06-11/30/12. USDA ( ): Northeast Region Center for the IR-4 Minor Crop Pest Management Program; Principal Investigator; $1,068,689; 4/15/10-4/4/12. USDA ( ): Northeast Region Center for the IR-4 Minor Crop Pest Management Program; Principal Investigator; $1,568,307; 9/1/09-8/31/11. Refereed publications: PUBLICATIONS Choi, J.-S. and D. M. Soderlund Structure-activity relationships for the action of 11 pyrethroid insecticides on rat Nav1.8 sodium channels expressed in Xenopus oocytes. Toxicol. Appl. Pharmacol. 211: Silver, K. S. and D. M. Soderlund Differential sensitivity of rat sodium channel isoforms to pyrazoline-type insecticides. Toxicol. Appl. Pharmacol. 214: Silver, K. S. and D. M. Soderlund Point mutations at the local anesthetic receptor site modulate the state-dependent block of rat Nav1.4 sodium channels by pyrazoline-type insecticides. NeuroToxicology 28: Soderlund. D. M Pyrethroids, knockdown resistance and sodium channels. Pest Manag. Sci. 64: Yoon, K, S., Symington, S. B., Lee, S. H., Soderlund, D. M. and J. M. Clark Three mutations identified in the voltage-sensitive sodium channel -subunit gene of permethrin-resistant human head lice reduce the permethrin sensitivity of house fly

7 Vssc1 sodium channels expressed in Xenopus oocytes. Insect Biochem. Mol. Biol. 38: Tan, J. and D. M. Soderlund Human and rat Nav1.3 voltage-gated sodium channels differ in inactivation properties and sensitivity to the pyrethroid insecticide tefluthrin. NeuroToxicology 30: Lee, S. H. and D. M. Soderlund Cloning and maintenance of the housefly sodium channel gene using low copy number vector and two sequential host strains. J. Asia- Pac. Entomol. 12: Breckenridge, C. B., Holden, L., Sturgess, N., Weiner, M., Sheets, L., Sargent, D., Soderlund,D. M., Choi, J.-S., Symington, S., Clark, J. M., Burr, S. and D. Ray Evidence for a separate mechanism of toxicity for the Type I and Type II pyrethroid insecticides. NeuroToxicology 30: S17-S31. He, B. and D. M. Soderlund Human embryonic kidney (HEK293) cells express endogenous voltage-gated sodium currents and Nav1.7 sodium channels. Neurosci. Lett. 469: Soderlund, D. M State-dependent modification of voltage-gated sodium channels by pyrethroids. Pestic. Biochem. Physiol. 97: Knipple, D. C. and D. M. Soderlund The ligand-gated chloride channel gene family of Drosophila melanogaster. Pestic. Biochem. Physiol. 97: Tan, J. and D. M. Soderlund Divergent actions of the pyrethroid insecticides S- bioallethrin, tefluthrin and deltamethrin on rat Nav1.6 sodium channels. Toxicol. Appl. Pharmacol. 247: Tan, J. and D. M. Soderlund Independent and joint modulation of rat Nav1.6 voltagegated sodium channels by coexpression with the auxiliary 1 and 2 subunits. Biochem. Biophys. Res. Commun. 407: Tan, J. and D. M. Soderlund Actions of tefluthrin on rat Nav1.7 voltage-gated sodium channels expressed in Xenopus oocytes. Pestic. Biochem. Physiol. 101: He, B. and D. M. Soderlund Differential state-dependent modification of rat Nav1.6 sodium channels expressed in human embryonic kidney (HEK293) cells by the pyrethroid insecticides tefluthrin and deltamethrin. Toxicol. Appl. Pharmacol., 257: Tan, J., J. S. Choi and D. M. Soderlund Coexpression with auxiliary subunits modulates the action of tefluthrin on rat Nav1.6 and Nav1.3 sodium channels. Pestic. Biochem. Physiol. 101: Soderlund. D. M Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances. Arch. Toxicol 86: von Stein, R. T. and D. M. Soderlund Role of the local anesthetic receptor in the statedependent inhibition of voltage-gated sodium channels by the insecticide metaflumizone. Mol. Pharmacol., 81: Soderlund, D. M Pyrethroid actions on sodium channels: isoform and species specificity. In "Parameters for Pesticide QSAR and PBPK/PD Models for Human Risk Assessment" (J. B. Knaak, C. Timchalk and R. Tornero-Velez Eds.), American Chemical Society, Washington DC, pp

8 McCavera, S. J. and D. M. Soderlund Differential binding of the pyrethroid insecticides S-bioallethrin, tefluthrin and deltamethrin to the open state of inactivation-deficient Nav1.6 sodium channels. NeuroToxicology 33: von Stein, R. T. and D. M. Soderlund Compound-specific effects of mutations at V787 in DII-S6 of Nav1.4 sodium channels on the action of sodium channel inhibitor insecticides. NeuroToxicology 33: von Stein, R. T., K. S. Silver and D. M. Soderlund Indoxacarb, metaflumizone and other sodium channel inhibitor insecticides: mechanism and site of action on mammalian sodium channels. Pestic. Biochem. Physiol. 106: He, B. and D. M. Soderlund Functional expression of rat Nav1.6 voltage-gated sodium channels in HEK293 cells: modulation by the auxiliary 1 subunit. PLoS ONE 9: e Soderlund, D. M Resmethrin, the first modern pyrethroid insecticide. Pest Manag. Sci. 71: He, B. and D. M. Soderlund Effects of the 1 auxiliary subunit on modification of Rat Nav1.6 sodium channels expressed in HEK293 cells by the pyrethroid insecticides tefluthrin and deltamethrin. Toxicol. Appl. Pharmacol. 291: Soderlund, D. M., J. Tan and B. He Functional reconstitution of rat Nav1.6 sodium channels in vitro for studies of pyrethroid action. NeuroToxicology (in press). Book chapters and symposium contributions (non-refereed): Soderlund, D. M Toxicology and mode of action of pyrethroid insecticides. In "Hayes' Handbook of Pesticide Toxicology, Third Edition" (R. I. Krieger, Ed.), Elsevier, New York, Vol. 2, pp