University of Florida College of Engineering EDGE Course EMA 6590/6938: Advances in Biomaterials and Tissue Engineering for Healthcare

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1 University of Florida College of Engineering EDGE Course EMA 6590/6938: Advances in Biomaterials and Tissue Engineering for Healthcare Catalog Description Use of new bioactive and bio-nano structures, surfaces and properties for healthcare applications, including tissue engineering, regenerative medicine, stem cell engineering, protein therapeutics, and bio-photonics testing of cell-material interactions. Socio-economic issues affecting cost and availability of new materials and technologies for healthcare. 3 Credit Hours Instructor Larry L. Hench, Adjunct Graduate Research Professor of Materials Science and Engineering (MSE) larryhench@embarqmail.com lhench@ufl.edu Textbooks [1] Biomaterials, Artificial Organs and Tissue Engineering Larry L. Hench and Julian R. Jones, eds; Woodhead Publishing, Cambridge, UK (2005) [2] Science, Faith and Ethics Larry L. Hench Imperial College Press, World Scientific Pub. Co. (2001) [3] Supplementary Readings in Biomaterials, Tissue Engineering and Healthcare Socio- Economics and Ethics Larry L. Hench, Editor Note: The textbook [1] includes a CD that contains 60 hours of illustrated lectures that cover topics in this course as well as self-paced study questions and answers. The textbook and CD module is specially designed for continuing education students that are off-campus or part-time. An additional instructional book is available for supplemental reading for each of the modules. It is listed as [3] Supplementary Readings in Biomaterials, Tissue Engineering and Healthcare Socio- Economics and Ethics. Course assessment will be based upon the content presented in the lectures, textbooks and supplemental reading material. Overall Objectives To introduce the students to recent developments in materials science and engineering directed to solve problems of survivability of biomaterials and devices in an aging population. The technological advantages and disadvantages, costs, risks, potential benefits and limitations, ethical and other healthcare issues associated with novel, molecularly tailored third generation materials and nano-materials are analyzed and compared with first and second generation biomaterials currently used for prostheses.

2 Specific Instructional Goals 1] Learn methods to analyze survivability, uncertainties and risk assessment of medical devices and compare with patient lifetimes. 2] Develop knowledge of new materials with bioactive properties and mechanisms of bonding and up and down regulation of genes to control cycles, proliferation and differentiation of cells. 3] Establish an understanding of the clinical applications of bioactive materials and their potential benefits and limitations based upon age and medical condition of the patient. 4] Develop knowledge of the effects of composition, size, surface and molecular structure of new nano-sized materials on their biological behavior and potential toxicology. 5] Learn and compare the concepts, processing, advantages and limitations of materials designed for use in tissue engineering, regenerative medicine, and protein therapeutics. 6] Develop knowledge of types of stem cells available for repair and regeneration of tissues and the effects of materials and scaffolds on control of stem cell proliferation and differentiation. 7] Develop an understanding of bio-photonics methods developed for testing safety, toxicology and efficacy of new biomaterials and nano-materials without use of animal testing. 8] Analyze the potential use of new materials in healthcare with respect to economics and ethical issues compared to present generations of biomaterials and medical devices. 9] Learn to compare the relative efficacy of alternative means of repairing tissues and organs by researching the literature and writing critical reviews. Course Assessment 1] The course is composed of three modules composed of nine hours of lectures per module; there are also four self-paced instructional hours per module using programmed text, CD, supplemental readings and study questions. 2] Three quizzes per module. (5% per quiz; 15 % of grade per module) 3] One Exam per module; (60% of grade per module) 4] One 1000 word essay per module (25% of grade per module) 6] Final Grade is based upon sum of % grade per module divided by 300%. 7] Grade scale: A=85-100, B= 70-84, C=55-69, D= 40-54, E=<39 Essays An essay containing approximately 1,000 words will be required for each module. The content of the essay is to be based upon the subject matter presented in the module. Select a topic of personal interest related to any of the lectures or reading assignments. Discuss the topic from your personal perspective as to why it is important and the scientific, technical, legal or moral issues involved. Include at least 4 recent references published in 2010 or 2011 that address the position you take regarding the topic. Internet references are acceptable but must include details of the site and date of access. Limit any quotes to no more than 40 words per quote. For full marks you must include at least one graphic illustration, figure or table (with citation) that supports the position you take in the essay.

3 University of Florida College of Engineering EDGE Course EMA 6938: Advances in Biomaterials and Tissue Engineering for Healthcare Lecture Schedule Module #1 First, Second and Third Generation Biomaterials Lecture Topic 1 Intro, Objectives, Assignments, Schedule, Assessments Frontiers of Knowledge 2 Cyborgs and Bionics: Science Fiction Meets Science Fact Spare Body Parts: The Good, The Bad, The Impossible? 3 Types of Tissue-Material Interactions First Generation Biomaterials: Bio Metals, Bioceramics Quiz #1 4 First Generation Biomaterials: Biopolymers 5 Second Generation Biomaterials: Resorbable Biopolymers 6 Bioactive Glasses: Compositions, Mechanisms of Bonding, Strength of Bonding, Class A and Class B Bioactivity Quiz #2 7 Third Generation Biomaterials: Controlled Ion Release, Cell Cycle Control, Gene Activating Glasses 8 Clinical Applications of Third Generation Biomaterials: Dental, Preventative 9 Clinical Applications of Third Generation Biomaterials: Orthopaedic, Spinal Surgery, Cranial, Maxillofacial Quiz #3 MODULE #1 EXAM Essay #1

4 Lecture Schedule Module #2 Tissue Engineering, Regenerative Medicine, Innovative Biomaterials Technologies Lecture Topic 10 Review of First, Second and Third Generation Biomaterials Regenerative Medicine Concepts: In Vitro vs In Situ Methods 11 Introduction to Sol-Gel Processing 12 Tissue Engineering (TE) Scaffolds: Requirements, Materials and 3-D Porosity Characterization Quiz #4 13 TE Cell Sources, TE Limitations and Barriers, Vascularization Bioactive Hybrid Inorganic-Organic TE Scaffolds 14 Nano-Bio Materials and Nano-Bio Technology Nano-Toxicology 15 Nano-Ceria Free Radical Scavenging Materials and Applications Quiz #5 16 Bio-Photonics: In situ Cell-Material Analyses of Cell Death, Cell Metabolism, Cell Cycle, Cell Differentiation 17 Stem Cell Technology: Hope vs Hype, Clinical Applications Barriers to the Clinic 18 Innovative Biomaterials: TheraSpheres Glass-Ceramic Dental Restorations Quiz #6 MODULE #2 EXAM Essay #2

5 Lecture Schedule Module #3 SOCIO-ECONOMIC and ETHICAL ISSUES IN HEALTHCARE 19 Technology Transfer in Healthcare: Pathways to Success 20 Technology Transfer in Healthcare: Barriers to Success 21 Regulatory Issues in New Medical Product Development: USA and EU Quiz #7 22 Ethical Issues: Principles of Moral Philosophy 23 Ethical Concerns in Implant Technology 24 Ethical Issues in Transplants, Stem Cell Technology Genetic Manipulation of Life Quiz #8 25 Ethical Issue Revisited: Value of Life? A Long Life at what Cost? 26 Healthcare Resource Allocations: Current Status Translation of New Technology from Lab to Clinic 27 The Future: Importance of Risk Assessment, risk/reward Ratios; Infinite Expectations vs Finite Resources; Challenges for Materials Science and Engineering Quiz #9 MODULE #3 EXAM Essay #3