Beyond Science to Solutions Tim Shannon VP & GM Global Orthopedics

Transcription

1 DSM in Biomedical Beyond Science to Solutions Tim Shannon VP & GM Global Orthopedics

2 The DSM Mission Our purpose is to create brighter lives for people today and generations to come We connect our unique competences in Life Sciences and Materials Sciences to create solutions that nourish, protect and improve performance Page 1

3 DSM has become a true global company Global workforce (FTE) Net sales by destination (%) North America > 3,000 Europe > 9,000 Asia > 6,000 10% 2% 3% 12% 3% 29% 12% 23% 6% JV s ~ 5,000 Latin America > 2,000 Africa: 73 employees RoW > 250 W-Europe Eastern Europe North America Latin America China India Japan Rest of Asia Rest of the World 56% employees outside Europe (2016) 65% sales outside Europe (2016) (37% *) (48% *) * As reported in 2006 Annual Report / 2006 Triple P report (not restated) Page 2

4 Key markets Dairy RTE meals Soups / Sauces / Spreads Wine-Beer-Fruit drinks Materials sciences (Food) Packaging Food & Beverages Other 8% 6% Building & 6% Construction 15% 6% Infant nutrition Automotive 7% 5% 11% Dietary Supplements Electrical & Electronics 31% 4% Personal Care Animal Feed Life sciences DSM offers products & solutions to a wide range of markets Page 3

5 Examples nutritional products of DSM Vitamins are essential nutrients required for growth and wellbeing. DSM has all 13 Vitamins including A, D, E, K, C, all B vitamins, folic acid and pantothenic acid Carotenoids: Essential antioxidants increasing performance and consistent pigmentation a/o for salmon, eggs Nutritional Lipids: Omega-3 and 6 play a critical role in proper brain function, vision process, immune and inflammatory responses and hormone-like molecules Feed Enzymes: Solutions developed to meet challenges of global livestock farming. Reducing costs by improving feed conversion and animal health Page 4

6 More examples of nutritional products Food & Beverage Enzymes: natural proteins that act as catalysts for biochemical reactions, used in dairy, baking, beverages, oil & fats and grain processing Minerals for animals that are needed by the body in very small amounts that cannot be made by living organisms Yeasts, cultures and probiotics: providing taste and texture and adding specific health benefits Page 5

7 Examples of materials of DSM DSM Engineering Plastics is supplier of high performance engineering thermoplastics as Stanyl, ForTii, ExoPaxx, Akulon, Arnite, Xytron, used in automotive, electronics, specialized industries and food packaging DSM Dyneema is the global supplier of Dyneema, the world s strongest fiber, used for medical sutures, fishing, aquaculture nets, ropes, slings, cut-resistant gloves, vehicle & personal ballistic protection Innovative resins for sustainable coatings systems, including: waterborne resins, powder resins and 100% UV curable resins High-performance UV-curable optical fiber materials for high-speed fiber networks connecting the world Page 6

8 DSM Innovation Center (DIC) Three attractive innovation platforms DSM Biomedical Innovative materials that deliver more advanced clinical procedures and improved patient outcomes DSM Bio-based Products & Services Advanced enzymes and yeast platforms: enabling advanced bio-energy and bio-based chemicals DSM Advanced Surfaces Smart coatings and surface technologies to boost performance in the solar industry Bringing Life Sciences and Materials Sciences competences together Page 7

9 Every 9 seconds, a patient receives a medical device containing a DSM biomedical technology An introduction to DSM in Biomedical Technology, material & capabilities portfolio

10 30 year track record in biomedical innovation and partnering DSM has a strong history of innovation Over $25M invested in research annually Over 400 Specialists 2009-Today 1902 DSM established : Founding of Kensey Nash acquired by DSM in : Polymer Technology Group established acquired by DSM in : Launched BioSpan, Bionate and Elasthane 95: Developed vascular closure device technology and degradable polymers : Contact lens material manufacturing 03: Launched Dyneema Purity fiber used in orthopedic sutures 04: First sales of Dyneema Purity fiber for knee ligament fixation; Bone void filler collaboration with partners 06: First sales of medical coatings 08: First cardiovascular & ophthalmic drug delivery development agreements; First sales of Dyneema Purity fiber in CV and spinal applications 11: Developed bioceramics technology; Actamax DSM-DuPont JV 13: FDA 510(k) clearance for Meso Bilayer Surgical Mesh; UHMWPE membrane technology 14: US Dyneema Purity fiber plant; Launched Dyneema Purity 10 dtex fiber and Radiopaque fiber; FDA 510(k) clearance for PRP Device 16: Drug delivery technology used in partner DES launch 09: Bionate II PCU; Developed ECM technology Page 9

11 DSM in biomedical Your biomedical partner, trusted by the medical industry to shape the future of medical devices with advanced healing technologies that improve and brighten patients lives throughout the world. Biomedical division of Royal DSM Exton, PA Geleen, The Netherlands Berkeley, CA Greenville, NC Page 9

12 Beyond Science to Solutions Global Partner DSM has unmatched global reach and resources Solutions Provider We have decades of successful research and scientific innovation Innovator We are addressing trends in medicine to create better outcomes for patients Page 11

13 Committed to grow your business DSM is a full service partner with an expansive global research and distribution network we turn ideas into high-quality solutions from biomedical materials and finished devices. Our business is guided by four basic principles: 1. Invest in advanced healing technologies to improve outcomes of patients 2. Leverage strong scientific and clinical history 3. Committed to reducing costs across the continuum of care 4. Provide the highest level of quality and integrated service to our partners Page 12

14 Deep understanding of our partners and clinical markets Market Growth Drivers Aging Population Rise in metabolic disease (Diabetes, Obesity) Premium placed on delivering positive clinical outcomes Product differentiation thru delivering healthcare economical value Market Challenges Outcomes Based Reimbursement Increased demands on efficacy and outcomes evidence Pricing Pressures Increasingly commoditized market Regulatory barriers Consolidation and integration Opportunities DSM brings Proven advanced healing solutions from biomaterials to finished devices Unmatched global reach and resources DSM s portfolio breadth provides single source solution to enable further integration and consolidation, reducing costs. Page 13

15 DSM technology continuum Solutions at all levels of the value chain Biomaterials to Finished Device Value RMM Formulation partner Material Provider Component Manufacturer Contract Manufacturer (build to spec) Medical Device Design Finished Medical Device Manf. Commercial Partner Page 14

16 Partnering from Concept to Commercialization Commercial Support Sales training / support Marketing support Clinical need Market research Conceptualization & Ideation Scientific research Fulfillment Quality assurance / Quality control Design Controls / Verification & Validation Manufacturing cgmp / ISO13485 Certified / 15 ISO Class 8 cleanroom suites Commercial Scale-up Dedicated Manufacturing Engineering & In House Tooling (CNC Mills & Lathes, Ram & Wire EDM, 3D Printing, Laser Systems) Biocompatibility & Preclinical testing Sterilization validation (Gamma, ETO, E-Beam) Analytical Testing (Mechanical, Chemical, Biological) Cell Culture Laboratory Research & Development Page Clinical & Regulatory 15 Regulatory support and/or approvals (PMA, 510K, CE Mark, Japan) IDE / Clinical Trials / ISO Clinical Evaluation Reports Packaging Design / Custom Packaging / IFU / Ship Shake / Shelf Life

17 Advanced healing technologies combine forward-looking science and proven clinical history An introduction to DSM s Biomedical business Technologies, material & capabilities portfolio

18 DSM in biomedical Broadest portfolio of advanced healing technologies and capabilities Biomedical Polyurethanes Coatings Hydrophilic Silicone Hydrogels Biomedical Polyethylenes Drug delivery Slow, sustained release Collagen ECMs Ceramics Polymer Processing Mechanical Devices Purified, Soluble & Fibrous Extracellular Matrices TCP, HA, Anorganic Bone PLA, PEEK, Polyurethane & UHMWPE Innovative devices and tooling Page 17

19 Water Resistant Adhesive *Profiled in July 19, 2007 issue Mimicking nature to create adhesive biomaterial Liquid Adhesive Sealant (spray or brush) Protective Coatings (anti-fouling, anti-adhesive) Adhesive Films OH OH Liquids Nature s Water Resistant Adhesive H 2 N CH 2 O OH 3,4-dihydroxyphenylalanine Critical Component Coatings Films Page 18

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