The Structure of Nucleic Acids DNA & RNA are POLYMERS of Each nucleotide is composed of:
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1 DA and rotein Synthesis - Life is a Three Letter Word! - CATER TES What is DA? DA is the control molecule of life. DA has three major functions: 1. DA CTRLS CELLULAR ACTIVITIES including reproduction. DA carries a CDE. Genetic instructions are encoded in the sequence of bases DA from male + DA from female = genetic information of offspring in sexual reproduction. DA instructions RA molecules proteins on which all forms of life are based.. DA MAKES EXACT CIES F ITSELF to pass onto other cells. RELICATI 3. DA UDERGES MUTATIS mutations and recombinations in DA molecules are the source of life's diversity. Linked to the Theory of Evolution explains all the species that have lived on this Earth. The Structure of ucleic Acids DA & RA are LYMERS of Each nucleotide is composed of: 1. a pentose (5 carbon). a group 3. a nitrogenous there are two types of bases: i) URIES - have a ring structure (adenine & guanine) - - C - - C nucleotide: base = Adenine nucleotide: base = Guanine ii) YRIMIDIES - have a ring structure (thymine, cytosine, uracil) 3 C - - C nucleotide: base = Thymine - - C nucleotide: base = Cytosine - - C eotide: base = Uracil RA LY nucl age 1
2 The DA strand DA strands are extremely long, each one containing millions of atoms. uman cells contains 1 m of DA 4 billion pairs of bases sequence of nucleotides linked together forms a (twisted ladder) Each strand alternating molecules of and deoxyribose nitrogenous base attached to sugar. -bonds between bases join the strands (rungs of the ladder) hydrogen bonds of DA in a very strict pattern. always a purine with a pyrimidine # of purine bases = # of pyrimidine bases. CMLEMETARY BASE AIRIG ADEIE (A) bonds with TYMIE (T) GUAIE (G) binds with CYTSIE (C) Complete the strand of DA A T G T G A T C C A C G C G T II II III II III II II III III II III III III III II GEES AD CRMSMES GEES Are the units of control of an organism. are located on the 1000 DA base-pairs control cellular chemical, by directing the formation of. characteristics like height and eye color are determined by combinations of several different genes
3 CRMSMES Are found in the 1 chromosome = 1DA Contain 175,000 genes in humans occur in genes do too. alf of each person's genes come from the and half from the. RELICATI - DA making identical copies of itself DA s structure has a natural mechanism for reproducing itself. Before a cell can divide, DA must be duplicated. This duplication process is called RELICATI. each strand of DA can be viewed as a template: like a potter's mold, it can produce a "reverse image" copy of itself (a complementary copy). Each new strand of DA produced has a sequence of bases exactly complementary to the template strand. Sequence of Events in Replication: 1. UZIIG: the DA double helix (helicase), and the two strands of DA separate; hydrogen bonds between the bases unwinding unzipping = breaking bonds 3
4 . CMLEMETARY BASE AIRIG: new nucleotides move in to pair up with bases of each strand of DA. These new nucleotides are always floating around within the nucleoplasm. 3. ADJACET UCLETIDES BD: sugarphosphate bonds form between adjacent nucleotides of the new strand to complete the molecule. The new molecule winds into a double helix. Base pairing Adjacent nucleotides bond FIAL RDUCT ew double strand of DA contains one "old" strand (the template) and one new strand. " " replication. half of the original molecule is conserved in each new molecule this ensures that there will be, replication of the parent molecule. this process proceeds by the action of several very specific (e.g. DA olymerases, gyrase, helicase) product of replication is two double-stranded DA molecules, each with one new strand and one original stand that acted as a template for replication. 4
5 What is DA? DA is the control molecule of life. DA has three major functions: 4. DA CTRLS CELLULAR ACTIVITIES including reproduction. DA carries a CDE. Genetic instructions are encoded in the sequence of bases DA from male + DA from female = genetic information of offspring in sexual reproduction. DA instructions RA molecules proteins on which all forms of life are based. 5. DA MAKES EXACT CIES F ITSELF to pass onto other cells. RELICATI 6. DA UDERGES MUTATIS mutations and recombinations in DA molecules are the source of life's diversity. Linked to the Theory of Evolution explains all the species that have lived on this Earth. The Structure of ucleic Acids DA & RA are LYMERS of UCLETIDES Each nucleotide is composed of: 4. a pentose (5 carbon) SUGAR 5. a SATE group 6. a nitrogenous BASE there are two types of bases: i) URIES - have a double ring structure (adenine & guanine) - - C - - C nucleotide: base = Adenine nucleotide: base = Guanine ii) YRIMIDIES - have a single ring structure (thymine, cytosine, uracil) 3 C - - C nucleotide: base = Thymine - - C nucleotide: base = Cytosine - - C eotide: base = Uracil RA LY nucl 5
6 The DA strand DA strands are extremely long, each one containing millions of atoms. uman cells contains 1 m of DA 4 billion pairs of bases sequence of nucleotides linked together forms a DUBLE ELIX (twisted ladder) Each strand alternating molecules of phosphate and deoxyribose sugar nitrogenous base attached to sugar. -bonds between bases join the strands (rungs of the ladder) hydrogen bonds of DA in a very strict pattern. always a purine with a pyrimidine # of purine bases = # of pyrimidine bases. CMLEMETARY BASE AIRIG ADEIE (A) bonds with TYMIE (T) GUAIE (G) binds with CYTSIE (C) Complete the strand of DA A T G T G A T C C A C G C G T II II III II III II II III III II III III III III II GEES AD CRMSMES GEES Are the units of inheritance control characteristics of an organism. are located on the chromosomes 1000 DA base-pairs control cellular chemical reactions, by directing the formation of enzymes. characteristics like height and eye color are determined by combinations of several different genes 6
7 CRMSMES Are found in the nucleus 1 chromosome = 1DA molecule Contain 175,000 genes in humans occur in pairs genes do too. alf of each person's genes come from the mother and half from the father.. RELICATI - DA making identical copies of itself DA s structure has a natural mechanism for reproducing itself. Before a cell can divide, DA must be duplicated. This duplication process is called RELICATI. each strand of DA can be viewed as a template: like a potter's mold, it can produce a "reverse image" copy of itself (a complementary copy). Each new strand of DA produced has a sequence of bases exactly complementary to the template strand. Sequence of Events in Replication: 3. UZIIG: the DA double helix unwinds (helicase), and the two strands of DA separate; hydrogen bonds between the bases break unwinding unzipping = breaking bonds 7
8 4. CMLEMETARY BASE AIRIG: new nucleotides move in to pair up with bases of each template strand of DA. These new nucleotides are always floating around within the nucleoplasm. 3. ADJACET UCLETIDES BD: sugarphosphate covalent bonds form between adjacent nucleotides of the new strand to complete the molecule. The new molecule winds into a double helix. Base pairing Adjacent nucleotides bond FIAL RDUCT ew double strand of DA contains one "old" strand (the template) and one new strand. "SEMI-CSERVATIVE" replication. half of the original molecule is conserved in each new molecule this ensures that there will be very, very accurate replication of the parent molecule. this process proceeds by the action of several very specific enzymes (e.g. DA olymerases, gyrase, helicase) product of replication is two identical double-stranded DA molecules, each with one new strand and one original stand that acted as a template for replication. 8
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