NANOTECHNOLOGY IN MEDICAL APPLICATIONS: THE GLOBAL MARKET
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1 NANOTECHNOLOGY IN MEDICAL APPLICATIONS: THE GLOBAL MARKET HLC069C September 2015 Paul Evers Project Analyst ISBN: BCC Research 49 Walnut Park, Building 2 Wellesley, MA USA (toll-free within the USA), or (+1) information@bccresearch.com
2 TABLE OF CONTENTS CHAPTER 1 INTRODUCTION 2 STUDY GOALS AND OBJECTIVES 2 REASONS FOR DOING THE STUDY 2 SCOPE OF REPORT 2 MARKET ANALYSES AND FORECASTS 2 METHODOLOGY 3 INTENDED AUDIENCE 3 INFORMATION SOURCES 3 ANALYST'S CREDENTIALS 3 RELATED BCC RESEARCH REPORTS 3 BCC RESEARCH WEBSITE 4 DISCLAIMER 4 CHAPTER 2 SUMMARY 6 DEFINITION OF NANOMEDICINE 6 RESEARCH AND COMMERCIALIZATION 6 APPLICATIONS 6 DRUG DELIVERY 6 DRUGS AND THERAPY 7 IN VIVO IMAGING 7 IN VITRO DIAGNOSTICS 7 BIOMATERIALS 7 ACTIVE IMPLANTS 7 MARKET 8 SUMMARY TABLE GLOBAL NANOMEDICINE MARKET BY THERAPEUTIC AREA, THROUGH 2019 ($ BILLIONS) SUMMARY FIGURE GLOBAL NANOMEDICINE MARKET BY THERAPEUTIC AREA, ($ BILLIONS) 8 9 CHAPTER 3 OVERVIEW 11 ABOUT NANOTECHNOLOGY 11 THE MANY USES OF NANOTECHNOLOGY 12 MEDICAL APPLICATIONS 12 ENVIRONMENTAL APPLICATIONS 12 MILITARY APPLICATIONS 13 COSMETICS 13 APPLICATIONS IN DEVELOPMENT 13 THE TOOLS OF NANOTECHNOLOGY 14 C60/FULLERENES 14 CARBON NANOTUBES 14 NANOPARTICLES 14 NANOWIRES 14 MOLECULAR NANOTECHNOLOGY 15 RISKS OF NANOTECHNOLOGY 15 POISON/TOXICITY 15 NANOTECHNOLOGY IN THE MARKETPLACE 16
3 MEDICAL NANOTECHNOLOGY - NANOMEDICINE 17 FUTURE POSSIBILITIES 18 MARKET POTENTIAL 18 CHAPTER 4 NANOMEDICINE 20 DEVELOPMENT OF NANOMEDICAL TECHNOLOGIES 20 TABLE 1 NANOMEDICINE ESTMIATED TIMESCALE BY DECADE 20 TABLE 2 MAIN NANOTECHNOLOGIES AND APPLICATIONS IN MEDICINE 21 LIPOSOMES 22 TABLE 3 MARKETED LIPOSOMAL NANOPHARMACEUTICAL PRODUCTS 22 DENDRIMERS 23 NANOCRYSTALS 23 TABLE 4 MARKETED NANOCRYSTAL PHARMACEUTICAL PRODUCTS 24 MICELLES 24 TABLE 5 MARKETED PRODUCTS IN MICELLE FORM 25 FULLERENES 25 POLYMERIC NANOPARTICLES 25 NANOPARTICLE-DRUG CONJUGATES 26 LIGAND-TARGETED NANOPARTICLES 26 CERAMIC NANOPARTICLES 26 VIROSOME NANOPARTICLES 27 CHAPTER 5 THERAPEUTIC USES OF NANOMEDICINE 29 CANCER DIAGNOSTICS AND THERAPY 29 SILICA NANOSPHERES 29 NANOSCALE HYDROGEL SHELLS 29 Carbon Nanoparticles 29 Photodynamic Therapy and Gold 30 Dendrimer Conjugates 30 Ligand-Targeted Emulsion Technologies 31 Linear Cyclodextrin-Containing Polymers 31 Smart Lipid-Based Nanocarriers 32 Thermotherapy Using Magnetic Nanoparticles 32 Targeted Cell Destruction 32 Nanoshells 33 DRUG DELIVERY 33 TABLE 6 MARKETED PRODUCTS WITH NANO-ENHANCED DRUG DELIVERY 34 AlphaRx 36 Aphios 36 Bind Biosciences 36 Biodelivery Sciences 37 Calando Pharmaceuticals Inc. 37 Capsulution NanoScience 37 Ceramisphere 38 CytImmune 38 Health Plus International 39 IGI Laboratories Inc. 39
4 Labopharm 39 MagnaMedics 40 Mebiopharm 40 Nanocopoeia 40 NanoCrystal 40 NanoMed 41 NanoCyte 41 NanoPharm 41 Nanotherapeutics 42 Nanotrope 42 psivida 42 Selecta Biosciences 43 SoluBest 43 Transave/Insmed 44 INFECTION CONTROL 44 Silver Nanoparticles against Infection 44 Detecting Nanobacteria 45 Killing Viruses 46 CHAPTER 6 DIAGNOSTIC TOOLS 48 PRACTICAL APPLICATION OF TOOLS 48 COMPANIES THAT DEVELOP THE TOOLS 48 BioCrystal/InVitrogen 48 BioForce 48 Biophage 48 CombiMatrix 49 Farfield Sensors 49 GE Healthcare BioSciences 49 Immunicon 50 MagnaMedics 50 Nanogen 51 Nanosphere 51 Qiagen 51 Sphere 52 TransGenex 52 Veredus 53 VARIOUS THERAPEUTIC TARGETS TECHNOLOGIES 53 Anthrax 53 Cholesterol 54 Artificial Retina 54 Nerve Regeneration 54 Crossing the Blood-Brain Barrier 55 Protecting Against Radiation Damage 55 Antibody Therapeutics 56 Hemostasis 56 Bone Fracture Repair 57 Dental Implant and Tissue Regeneration 57
5 Vaccine Adjuvant 57 Treatment of Thrombosis 58 Coatings for Stents and Other Devices 58 CHAPTER 7 FUTURE TRENDS AND RESEARCH POSSIBILITIES 61 NON-INVASIVE NANODEVICES 62 EXTRACELLULAR DEVICES 62 INTRACELLULAR DEVICES 63 NANOMACHINES TO CONTROL TISSUE HEALING 63 ELIMINATING VIRUSES 64 CORRECTING CHEMISTRY 64 NEW ORGANS AND LIMBS 65 FUNDAMENTAL NANOTECHNOLOGY RESEARCH 65 UNITED STATES 66 University at Albany-SUNY 66 Cornell University 66 University of Michigan 67 Rice University 67 University of Pennsylvania 68 University of Virginia 68 University of North Carolina 68 Ohio State University 69 Northwestern University 69 University of Pittsburgh 69 Case Western Reserve University 70 University of California at Berkeley 70 EUROPE 70 TABLE 7 EUROPEAN NANOCENTRES 71 JAPAN 72 Development of Active Targeting DDS 72 Development of Novel Tissue Engineering 72 Development of New Biomaterials 72 THE RISK FACTOR 73 CHAPTER 8 MARKETS FOR NANOMEDICINE 76 TABLE 8 MARKETED NANOPHARMACEUTICALS 76 TABLE 9 MARKETED NANO-IMAGING, DIAGNOSTICS AND BIOMATERIALS 77 MARKET DRIVERS 78 MARKET ESTIMATES AND FORECASTS 79 TABLE 10 GLOBAL MARKET SHARE FOR NANOTECHNOLOGY BY INDUSTRY SECTOR, 2010 (%) GLOBAL NANOMEDICINE MARKET 79 TABLE 11 GLOBAL NANOMEDICINE, NANOPHARMACEUTICAL AND NANODIAGNOSTIC MARKET, THROUGH 2019 ($ BILLIONS/%) MAIN PRODUCT CATEGORIES 80 DRUG DELIVERY 80 MOLECULAR DIAGNOSTICS 81 MARKET ANALYSIS BY CLINICAL APPLICATION
6 Cancer 82 TABLE 12 MAJOR MARKETED ANTICANCER NANOPHARMACEUTICAL PRODUCTS BY COMPONENT, MANUFACTURER AND SALES ($ MILLIONS) TABLE 13 GLOBAL MARKET FOR CANCER NANOTHERAPEUTICS AND NANODIAGNOSTICS ($ BILLIONS) CNS Disorders 83 TABLE 14 MAJOR MARKETED CNS NANOPHARMACEUTICAL PRODUCTS BY COMPONENT, MANUFATURER AND SALES ($ MILLIONS) TABLE 15 GLOBAL MARKET FOR CNS NANOMEDICINES 83 Infection 83 TABLE 16 MAJOR MARKETED ANTI-INFECTIVE NANOPHARMACEUTICAL PRODUCTS BY COMPONENT, MANUFACTURER AND SALE ($ MILLIONS) TABLE 17 GLOBAL MARKET FOR ANTI-INFECTIVE NANOMEDICINE, NANOTHERAPEUTICS AND NANODIAGNOSTICS ($ BILLIONS) Cardiovascular and Autoimmune Disorders 84 TABLE 18 MAJOR MARKETED NANOMEDICINE PRODUCTS FOR CARDIOVASCULAR AND INFLAMMATORY DISEASES BY COMPONENT, MANUFACTURER AND SALE ($ BILLIONS) TABLE 19 GLOBAL MARKET FOR CARDIOVASCULAR AND ANTI-INFLAMMATORY NANOPRODUCTS ($ BILLIONS) REGIONAL MARKET ANALYSIS 85 U.S. 85 TABLE 20 U.S. NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) 86 Japan 86 TABLE 21 JAPANESE NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) 86 Europe 87 TABLE 22 GERMAN NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) 87 TABLE 23 FRENCH NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) 87 TABLE 24 UNITED KINGDOM NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) TABLE 25 ITALIAN NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) 87 TABLE 26 BELGIUM AND NETHERLANDS NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) TABLE 27 SPANISH NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) CHAPTER 9 COMPANY PROFILES 91 COMPANIES THAT COMPRISE THE GLOBALNANOMEDICINE INDUSTRY 91 ABLYNX NV 91 ABRAXIS BIOSCIENCE INC. 92 ACRYMED INC. 93 ACUSPHERE INC. 94 AMAG PHARMACEUTICALS INC. 95 ALLTRACELL 96 ANSON NANO-BIOTECHNOLOGY 97 APHIOS CORP. 97 Protein Nanoparticles 98 Polymer Nanospheres 98 Phospholipid Nanosomes 98 BIND THERAPEUTICS INC. 99
7 BIOCRYSTAL LTD. 100 BIOFORCE NANOSCIENCES INC. 101 The ViriChip Virus Detection Platform 101 BIO-GATE AG 101 Medical Applications 102 BIOPHAGE PHARMA INC. 103 BioPhage Products 103 Development through Collaborations: 103 Phages 104 BIOPHAN TECHNOLOGIES INC. 104 CALANDO PHARMACEUTICALS INC. 105 About CALAA C SIXTY INC. 107 COMBIMATRIX CORP. 108 Drug Development 108 ELAN DRUG TECHNOLOGIES 109 FARFIELD SCIENTIFIC 111 GE HEALTHCARE 112 IGI LABORATORIES INC. 113 KEREOS INC. 114 KER KER KER KEYSTONE NANO INC. 115 NanoJackets 115 KLEINDIEK NANOTECHNIK GMBH 116 NanoWorkstation 117 LABOPHARM INC. 117 LIPLASOME PHARMA A/S 118 LUMERA CORP. 119 Product Portfolio 120 Nanocapture Microarrays 120 MAGFORCE NANOTECHNOLOGIES AG 120 MAGNAMEDICS GMBH 122 Diagnostics: 122 Efficient and Low-Cost Diagnostics 123 Multifunctional Drug Carrier 123 MICROFLUIDICS INTERNATIONAL CORP. 123 MIDATECH PHARMA PLC 124 MIV THERAPEUTICS INC. 126 Cardiovascular Heart Stents 126 MOLECULAR PROFILES (NOW JUNIPER PHARMACEUTICALS ) 127 NANOBAC PHARMACEUTICALS INC. 128 NANOBIO CORP. 129 NANOBIOTIX 131 NANOCARRIER CO. LTD. 133 NANOCOPOEIA INC. 134
8 NANOCYTE INC. 135 NANOGEN INC. 136 Electronic Microarray 136 Instrumentation 137 Molecular Biology Workstation 137 Molecular Biology Workstation Cartridge 137 NanoChip 400 System 137 NANOLOGIX INC. 138 NANOMED PHARMACEUTICALS INC. 139 NANOMIX INC. 140 NANOSPECTRA BIOSCIENCES INC. 141 NANOSPHERE INC. 142 NANOSTRUCTURES INC. 143 NANOSYN INC. 144 NANOTHERAPEUTICS INC. 145 NANOTROPE INC. 148 Technology 149 NANOVIRICIDES INC. 149 Pipeline 150 NUCRYST PHARMACEUTICALS 151 NUTRALEASE LTD. 152 ORION INTEGRATED BIOSCIENCES INC. 152 Genomic Signatures 153 Rational Antiviral Development 153 Discovery of Malaria Invasion Pathways 154 ORTHOVITA INC. 154 PIONEER SURGICAL TECHNOLOGY 155 PSIVIDA LTD. 155 QIAGEN NV 157 SOLUBEST LTD. 158 STARPHARMA 159 Dendrimer Nanotechnology 160 TECAN GROUP LTD. 160 TRANSGENEX NANOBIOTECH INC. 161 Therapy 161 CHAPTER 10 APPENDIX 164 GLOSSARY 164
9 LIST OF TABLES TABLE HEADING SUMMARY TABLE GLOBAL NANOMEDICINE MARKET BY THERAPEUTIC AREA, THROUGH 2019 ($ BILLIONS) TABLE 1 NANOMEDICINE ESTMIATED TIMESCALE BY DECADE 20 TABLE 2 MAIN NANOTECHNOLOGIES AND APPLICATIONS IN MEDICINE 21 TABLE 3 MARKETED LIPOSOMAL NANOPHARMACEUTICAL PRODUCTS 22 TABLE 4 MARKETED NANOCRYSTAL PHARMACEUTICAL PRODUCTS 24 TABLE 5 MARKETED PRODUCTS IN MICELLE FORM 25 TABLE 6 MARKETED PRODUCTS WITH NANO-ENHANCED DRUG DELIVERY 34 TABLE 7 EUROPEAN NANOCENTRES 71 TABLE 8 MARKETED NANOPHARMACEUTICALS 76 TABLE 9 MARKETED NANO-IMAGING, DIAGNOSTICS AND BIOMATERIALS 77 TABLE 10 GLOBAL MARKET SHARE FOR NANOTECHNOLOGY BY INDUSTRY SECTOR, 2010 (%) TABLE 11 GLOBAL NANOMEDICINE, NANOPHARMACEUTICAL AND NANODIAGNOSTIC MARKET, THROUGH 2019 ($ BILLIONS/%) TABLE 12 MAJOR MARKETED ANTICANCER NANOPHARMACEUTICAL PRODUCTS BY COMPONENT, MANUFACTURER AND SALES ($ MILLIONS) TABLE 13 GLOBAL MARKET FOR CANCER NANOTHERAPEUTICS AND NANODIAGNOSTICS ($ BILLIONS) TABLE 14 MAJOR MARKETED CNS NANOPHARMACEUTICAL PRODUCTS BY COMPONENT, MANUFATURER AND SALES ($ MILLIONS) TABLE 15 GLOBAL MARKET FOR CNS NANOMEDICINES 83 TABLE 16 MAJOR MARKETED ANTI-INFECTIVE NANOPHARMACEUTICAL PRODUCTS BY COMPONENT, MANUFACTURER AND SALE ($ MILLIONS) TABLE 17 GLOBAL MARKET FOR ANTI-INFECTIVE NANOMEDICINE, NANOTHERAPEUTICS AND NANODIAGNOSTICS ($ BILLIONS) TABLE 18 MAJOR MARKETED NANOMEDICINE PRODUCTS FOR CARDIOVASCULAR AND INFLAMMATORY DISEASES BY COMPONENT, MANUFACTURER AND SALE ($ BILLIONS) TABLE 19 GLOBAL MARKET FOR CARDIOVASCULAR AND ANTI-INFLAMMATORY NANOPRODUCTS ($ BILLIONS) TABLE 20 U.S. NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) 86 TABLE 21 JAPANESE NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) 86 TABLE 22 GERMAN NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) 87 TABLE 23 FRENCH NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) 87 TABLE 24 UNITED KINGDOM NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) TABLE 25 ITALIAN NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) 87 TABLE 26 BELGIUM AND NETHERLANDS NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) TABLE 27 SPANISH NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%)
10 LIST OF FIGURES FIGURE TITLE SUMMARY FIGURE GLOBAL NANOMEDICINE MARKET BY THERAPEUTIC AREA, ($ BILLIONS) 9
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