Instructor: Dr. Kelly Cude. Course Syllabus

Transcription

1 BIO 240 Spring 2015 Instructor: Dr. Kelly Cude Course Syllabus Course Meeting Times M, W 9:30am -10:50am W 11:00am -2:05pm Instructor Office Hours M: 11:30-1:00 pm BONH 319 T: 11:00-12:30 BONH 319 by kelly.cude@canyons.edu Textbook (1) Introduction to Genetic Principles by David Hyde,McGraw Hill, First Edition, 2009 (2) BIO 240 Lab Manual (from the campus bookstore) Course Blackboard Website: login: student ID#, password: student. Student Learning Outcomes (SLOs) Lecture: (1) Analyze the structure, function, and regulation of genes and their products as they relate to cellular function and genetic diseases. (2) Evaluate patterns of genetic inheritance using Mendelian and Non-Mendelian methods of gene transmission. Lab: (1) Perform genetic analysis using a variety of experimental techniques. (2) Execute bioinformatics and statistical modeling to analyze biological data. Important Dates Drop Deadline (no W): February 22, 2015 Withdrawal Deadline (W): May 8, 2015 Last Day of Class: June 3, 2015

2 Lecture Assessment: Exams will cover lecture material and will consist of short answer questions. Prior to each exam, problem sets will be posted to Blackboard with study questions designed to help you prepare for each exam. Problem sets are meant to act as study guides and will not be graded. Lab Assessment: Read lab materials BEFORE coming to lab and BE ON TIME! Quizzes will be given at the start of lab periods and will cover material from the previous week s lab and the current day s lab. I will drop your lowest lab quiz. Completed lab reports will be due ONE WEEK after completing the entire lab (may be multiple days of experiments). The lab final will be a cumulative practical and consist of fill-in short answer questions worth 100 points. Course Evaluation Grade Scale 4 Exams 100 pts/each % A Lab Reports 100 pts 80-89% B Lab Quizzes 70 pts 70-79% C Lab Final 100 pts 60-69% D Total 670 pts < 60% F Plagiarism: COC has a zero tolerance policy on cheating. Any student caught cheating will immediately receive a failing grade (F) for this course. Cheating includes talking during the exam, passing notes during an exam, coping from another student s exam or work, producing unoriginal work (ie copying directly from the text w/o citing), using cheat sheets, cell phones, ipods, or other unauthorized written or verbal sources on an exam. Grading and Makeup Exam Policies: I generally do NOT offer make up exams. Requests for makeup exams are only warranted in cases of extreme illness or family emergency. Arrangements for makeup exams must be made BEFORE the scheduled exam period and will require appropriate documentation such as a physician s note.

3 Important Degree Information Check out the Math-Sciences Division website to see which classes are required for various degree programs and/or to see if you qualify to graduate with one of these degrees: ASSOCIATE DEGREE INFORMATION Recent California Legislation guarantees admission to a California State University (CSU) campus for any community college student who completes an associate degree for transfer. The Associate in Science for Transfer (AS-T) in Math, Physics, Computer Science, and Geology, or the Associate in Arts for Transfer (AA-T) in Geography, is intended for College of the Canyons students who plan to complete a bachelor's degree in a similar major at a CSU campus. Students must earn a C or better in all courses required for the major or area of emphasis. The College also offers associate degrees in Biology, Computer Science, Engineering, and Math. For more information on the suggested sequence of classes to be taken in order to obtain these degrees in two years, as well as information on when these courses are guaranteed to be offered, please visit: Additional Resources MATHEMATICS, ENGINEERING, SCIENCE ACHIEVEMENT (MESA -ALLB 114): MESA is a program that supports students to excel in math, engineering, and the sciences. MESA is based on a rigorous program that builds academic skills and encourages cooperative solving. There is access to technology, academic advisement, and other support services are available. For more information, please contact the MESA Program Director in ALLB-114 or call (661) DISABLED STUDENTS SERVICES (DSPS): COC provides services for students with disabilities in compliance with the American Disabilities Act (ADA) and Section 504 of the Rehabilitation Act of If you need special accommodations please see me early in the semester. The DSP&S Office is located in Seco Hall, room 103 (behind financial aid). Phone Number: (661) ; Telephone Devise for the Deaf (TTY): (661) THE LEARNING CENTER: For tutoring in English, Math, Science, and other subjects on a walk-in basis, please visit the state-of-the-art TLC. Call for hours of operation at If you are having trouble--contact me, form a study group or study with a friend, and use the TLC services. Seek help as soon as you need it, the college has many resources, don t wait until it s too late!

4 Note: schedule is subject to change at discretion of instructor Section 1: February 9 th March 9th First Section Topics Chapter 2/9 Introduction to Genetics 1 (2-10, 12-17) - history of genetics, model organisms - classical vs. molecular genetics 2/11 2/18 Mendelian Genetics & Probabilities 2 - monohybrid/dihybrid crosses - sum and product rules - Chi square analysis Mon 2/16 *** President s Day Holiday *** 2/23 Pedigree Analysis 4 (82-88) dominant vs recessive autosomal vs sex-linked 2/25-3/2 Non-Mendelian Patterns of Inheritance 5 - variations in dominance - complementation - penetrance/ epistasis Ecstatic Girl Epistasis Activity 3/4 3/9 Sex Determination & Sex Linked Genes 4 (69-82) - XY system, XO, haplo-diplo systems *Figs environmental control of sex determination - sex chromosome aneuploids, (nondisjunction) - Turners, Kleifelters, AIS, Metafemale, Supermale WED 3/11 *** EXAM 1 ***

5 Section 2: March 16 th - April 15 th Second Section Topics Chapter 3/16 3/18 DNA Structure & Classic Experiments 7( ) - Griffiths, Hershey-Chase, Avery-McLeod *Figs Chargaff, Franklin, Watson-Crick - Meselson-Stahl DNA replication - B vs. Z form DNA, telomeres 3/23-3/25-3/30 Central Dogma Brief Overview 10(263-66) - transcription of mrna 11( ) - mrna splicing/intron removal - The Genetic code Review Figures - translation of proteins 10.2, 10.8, 10.26, 11.10, 11.21, Hey Sherlock Central Dogma Activity 3/30-4/1-4/13 Gene Activation & Regulation (EUK) 10(278-84, ) - promoters & transcription factors 17(564-72, ) - enhancers, cell specific expression 17(591-93, ) - chromatin remodeling/ histone acteylation - alternate splicing - mirna, antisense RNA - post-translational modifications April 6-10 **SPRING BREAK ** WED 4/15 *** EXAM 2 ***

6 Section 3: April 20 th May 13 th Section 3 Topics Chapter 4/20-4/22 Genetics of Bacteria & Viruses 15 ( ) - Conjugation, transduction, transformation - Hfr and recombinant phenotypes - lytic vs. lysogenic 4/27-4/29 Gene Activation & Regulation (Bacteria) 16 ( ) - lac and trp operons - allosteric regulation - negative vs. positive reguation - inducible & repressible systems 5/4-5/6 DNA Mutations and Repair 18( ) - point mutations 20( ) - base damage/adducts/dsb - somatic vs. germline - spontaneous vs. induced - detection and repair 5/11 Dynamic Genome: Transposable Elements 18( ) -McClintock Experiments -autonomous/nonautonomous - DNA transposons vs. Retrotransposons - Alu, LINES, SINES WED 5/13 *** EXAM 3 ***

7 Section 4: May 18 th June 3 rd Section 4 Topics Chapter 5/18 Linkage Analysis 6( , ) - 3 point cross (ON BOARD ACTIVITY) - Recombination Frequency Beetle Mania Activity-Handout 5/18 5/20 Genomics/Bioinformatics 13 - gene annotation - BLAST - genomic libraries - conserved protein domains MON 5/25 *** Memorial Day Holiday*** 5/27-6/1 Gene Isolation & Manipulation 12 - vectors/ subcloning/ screening - nucleic acid probes/ blots - transgenics/cloning - genetically modified food/ animals WED 6/3 ***EXAM 4 ***