MEMS: Sensing a New World of Applications in Healthcare and Wellness
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1 MEMS: Sensing a New World of Applications in Healthcare and Wellness Jay Esfandyari MEMS Product Marketing Manager Medical Technology Conference Tempe, AZ, Sep. 2013
2 Health and Wellness More than one billion adults overweight world wide 2 Healthy Family Worried well vital sign monitoring: Weight Blood pressure Glucose Cholesterol Activity level Benefits: Monitor and motivate Achieve individuals goals Access personal fitness information anywhere Enhance trainers services Blood-pressure Cuff Pedometer Weight Scale Heart Strap Digital Home Cell Phone Fitness Equipment Medication Tracking PC Internet Weight loss and fitness coaching Healthcare Professionals Personal Health Record
3 Disease Management More than 900 million chronic disease patients world wide 3 Vital sign monitoring: (remote patient monitoring) Diabetes COPD CHF Hypertension Chronic disease Post trauma Pre-op Blood-pressure Cuff Pedometer Weight Scale Fitness Equipment Pulse Ox Medication Tracking Thermometer Digital Home Cell Phone Personal Health System Glucose Meter PC Internet Benefits: Provide better-coordinated care Connect to care team Empower individuals Encourage early detection Reduce costs Family Care Givers Disease Management Service Healthcare Provider Personal Health Record
4 Aging Independently More than 600 million elderly individuals world wide 4 Independent living Chronic disease Basic life monitoring: Bed pressure (sleep) Bathroom sensor Gas / water sensor Emergency sensor Pulse Ox Benefits: Involve family members Allow remote analysis & care Provide integrated view Encourage early detection Reduce costs Blood-pressure Cuff Pedometer Home Automation & Control Fitness Equipment Medication Tracking Digital Home Cell Phone Personal Health System Internet Family Care Givers Elderly Monitoring Services Diet and Wellness Services Disease Management Service, Healthcare Provider
5 MEMS Technology for Sensors 5 Technologies Process Modules & Materials Material Substrate Silicon, Glass Flexible Biocompatible material (polyimide) Dry and Wet etching Permanent and Photosensitive: from 1 to 20 um Physical Vapor Deposition: e-beam, sputtering Chemical Vapor Deposition Electroplating: Au up to 20um MEMS technology can be used to produce geometrically well defined, highly reproducible structures and surfaces area. Full range of Metals Ag, Au, Al, Ir, Cr, CrSi, Cu, Fe, Ni, Pd, Pt, Co Full range of dielectric materials SiNx, SiOx, SiON One & Double side Lithography Dry and Wet Etch Wafer/Wafer Bonding
6 Advantages of MEMS MEMS technology is mainly based on silicon, which interferes less with body tissues 6 Small size, high functionality, high precision, accurate, low cost, low latency, high level of integration, low power consumption, High volume production capability can significantly reduce cost Multiple components can be integrated on a single chip Smaller volumes of reagent samples for analysis are possible Less painful as they are less invasive Long battery life due to ultra low current consumption.
7 Challenges of MEMS Packaging, fabrication processes and materials remain the biggest hurdle for MEMS medical devices: Bio-compatibility: the device should be benign and non-toxic to surrounding tissues. Hermeticity: The device environment is usually harsh and the reactions should be minimized or reduced. E.g. Blood is considered highly corrosive. 7 Long time from proof of concept to prototype and then through FDA approval Life of the device Retrieving data from the device Resist drifting along with the body fluids
8 Physical Sensors 8 Accelerometer Gyroscope Magnetometer Microphone Pressure Sensor Strain Gauge Microfluidic
9 Biosensors and Biochips 9 Bio-chemical Sensors Glucose Sensors (CGM) Contact Lens Sensor Sensor in extreme environmental Diagnostics & Monitoring Molecular Diagnostics LabOnChip Vere Flu Vere Foodborne Vere Threat Vere MTB-MDR Vere Trop Vere FingerPrint Real time PCR Therapeutics Personal Care Infusion: Microfluidic MEMS for Drug delivery Transdermal uneedles Injectable Implantable Diagnostics Home care On-Site Patient monitoring
10 MEMS Enable a World of Applications 10 Sensors : ph, humidity, Oxygen, CO2, Blood gas analysis, Continuous Glucose Sensors, Other chemicals Respiratory equipment Bio-reactors, agriculture Toxicants detection Food monitoring ECG (Analog) Glaucoma Lens (MEMS) Insulin Nano pumps (MEMS) Lab-on-Chip (MEMS)
11 MEMS Accelerometers Accelerometer is a system based on silicon mechanical structure able to sense motion 11 Vibration (dynamic measurement) Inclination (static measurement) Acceleration (dynamic measurement) Physical activity monitoring Involuntary hand motion ( Parkinson s disease,..) Adjusting stimuli levels in pacemakers
12 Man-Down Solution 12 Based on a 3D digital accelerometer and a digital pressure sensor Sensor fusion algorithms help to reduce false triggering of rescue calls The algorithm, optimized for sensors placed on the belt or at waist level, is very light and designed to be executed on low power computational systems.
13 Disposable Sensor for Early Diagnosis of Glaucoma Strain gauge & antenna embedded in a silicone contact lens The Sensor is capable of measuring cornea deformations due to Intra-Ocular- Pressure (IOP) variations The IOP Sensor is a wireless sensor that acts as a transducer, antenna and mechanical support for additional readout electronics Triggerfish System has been developed by SENSIMED AG. Application: Contact Lens for early diagnosis and treatment of Glaucoma ST Wafer containing contact lens sensor The complete (Smart) System commercialized by SENSIMED includes: - Contact Lens - External antenna & data-cable - Recorder - Software Contact lens sensor Into the patient s eye 13 Sensor is a strain gauge & antenna embedded in a silicone contact lens Telemetric chip
14 BodyGuardian Preventice Solution Medical device and mobile health solution to prescreen and actively monitor abnormal heart conditions. Mayo Clinic research and clinical trials Monitors EKG, heart rate, breathing rate, activity level, and body position Use case combine with medication management for day remote monitoring of coronary stent patient Future use cases for fitness oriented people as mobile comprehensive heart rate monitor Captured Medical Information for Physicians and Medical Professionals with ipad
15 Sensors for Activity Monitoring Human body tracking using sensor fusion: fall-detection of senior people golf swing motion capture sports collision detection 15 Sensors can be used to track human body motion: head movement arm or leg movement body jump twist motion, etc. For example: This can be used to model the gait of a person for dead reckoning development.
16 Addressing the needs of an aging population Lowering healthcare system costs Low power, Battery Operated Energy Harvestng Body Area Network New Trend Insulin- Pump System Body Area Network Glaucoma Sensor Sensor Node 1 Sensor Node 2 Sensor Node 3... Products High-Performance MEMS Accelerometers, Gyros Pressure Sensors, uphone Strain Gauge RF Transceivers Analog precision human interface, eg:ecg Low power uc/mcu Power Mgmt, Signal condition, Thin Film Battery 16 Benefits of MEMS-based Solutions: Vital-Sign Monitor ECG Ergonomically Friendly Band-Aid type patch Sensor Network: Sensors will talk to each other Accuracy of Sensors Non-Invasive Technique Low Cost for Public Healthcare Service 24h Monitoring
17 Tele-Health Remote Monitoring 17 Band-aid or T-Shirt Aging population GPRS Care Server Bluetooth DUN Internet ADSL Bluetooth Internet Bluetooth SPP Tele-Health Off-body sensors User IP Box Doctor/User PC GPS location Keep people out of the hospital Continua Health Alliance Interoperability Tele-Health, Remote Patient Monitoring, Home Health, Personalized Medicine, Tele-medicine. Continua/Connectivity Driven (USB, BTLE, BT); ECG & Holter Monitors; Breathing Rate; Activity Level; Body Position; Temperature; Blood Testing
18 Looking Ahead MEMS will continue to growth fast and enable a revolution in Healthcare Advanced Technologies & Design Best-in-Class Manufacturing New Applications THANK YOU
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