Mouth Guards, Sweatbands, and Bandages: On-body Chemical Sensors. Christopher Salthouse, Dev and Linda Gupta Professor of Electrical Engineering

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1 Mouth Guards, Sweatbands, and Bandages: On-body Chemical Sensors Christopher Salthouse, Dev and Linda Gupta Professor of Electrical Engineering

2 Know Your Health Continuous Chemical Monitoring Bandage Sweatband Mouthguard

3 Personalized Health Monitoring Physiological Monitoring ($6.2 B) In Vitro Diagnostics ($48 B) Wearable Technology Point-of-Care Diagnostics ($8.7 B) Personalized Health Monitoring

4 Physiological Monitoring Pulse Oximeter GE Healthcare LEDs Photodiodes Accelerometers (to remove motion artifacts) Holter Monitor Electrodes Accelerometers (to remove motion artifacts) Drugs.com Patient Monitor GE Healthcare Optics Electrodes Accelerometers

5 Talk Organization Current Clinical Measurements Products Under Development What is Next?

6 In Vitro Diagnostics Complete Blood Count (CBC) Liver Panel Kidney Panel Blood Sugar Blood Lipid

7 In Vitro Diagnostics: Cell Counters Complete Blood Count (CBC) Liver Panel Kidney Panel Blood Sugar Blood Lipid

8 In Vitro Diagnostics: Chemical Analyzers Technology Colorimetry Turbidmetry Homogeneous EIA Indirect ISE

9 Point of Care Diagnostics Pregnancy Blood Glucose Flu Fecal Blood

10 Lateral Flow Assay Cheap, Easy Low Sensitivty

11 Microfluidic Sample Reagent 1 Waste Reagent 2

12 Microfluidic Complex High Performance

13 Electrochemical Detection Low Cost Good Sensitivity

14 Fluorescence Detection Targeted Fluorophore handbook/figures/1622.html Activatable Fluorophore

15 Fluorescence Imaging in Biology B. N. Giepmans, S. R. Adams, M. H. Ellisman, and R. Y. Tsien, "The fluorescent toolbox for assessing protein location and function," Science, vol. 312, pp , Apr

16 Talk Organization Current Clinical Measurements Products Under Development What is Next?

17 Physical Sensor: Pulse Oximeter Bandage Key Features Self Contained Single Use Fully Printed

18 Shrinking the Microscope No Filters No Lenses Single Chip Solution

19 Big Ideal #1: No Magnification Needed

20 Big Ideal #2: No Lens Needed I( h,r) = h ( h 2 + r 2 ) 3 2

21

22 Big Idea #3: No Filtering Needed

23 Fluorescent Lifetime Multiplexing

24 Measuring Time-Domain Fluorescence

25 Time Domain Fluorimeter

26 TDF: Measuring Fluorescent Lifetime

27 Dual Fluorophore Multiplex Probe C. Salthouse, F. Reynolds, J. Tam, L. Josephson, and U. Mahmood, Quantitative Measurement of Protease-Activity with Correction of Probe Delivery and Tissue Absorption Effects Sensors and Actuators B: Chemical in press

28 Microfluidic Device

29 Automation of flow cytometer with version 2

30 Results LFI of commercially available fluorescence beads LFI of fluorescently stained live cells

31 Results Cont.

32 Talk Organization Current Clinical Measurements Products Under Development What is Next?

33 Bandage Sensor Physical Sensors Accelerometer Temperature Humidity Light Sunscreen Chemical Sensor Sweat Environmental

34 Sweat Band Physical Sensors Gestures Chemical Sensor Sweat Environmental

35 Mouth Guard Physical Sensors Concussion Sensor Chemical Sensor Saliva Breath Gases Exhaled Volatile Organic Compounds

36 Continuous Detection

37 UMass is Investing $45 Million in Personal Health Monitoring

38 CPHM is a Place

39 CPHM Makes Things qdot CMOS IC Char. HHFIB CMOS++ Sensor Integration Product Human Tech Prototype Rapid Proto Lab Prototype

40 Characterization Lab Confocal Microscope Particle Sizer Mechanical Tester Optical Plate Reader FTIR Spec Multi-Dimension Mech Test

41 HHFIB Fabrication Furnace Sputterer PECVD Dry Etch

42 HHFIB Testing Probe Station 1 THz Network Analyzer THz Laser THz Spectrometer

43 Rapid Prototyping Lab CubeX-FDM spro-dms Eden 500 3d Inkjet ProJet - SLA Laser Cutter Kern - MicroMill

44 Sensor Integration Lab Flipchip Bonder X-Ray Inspection Wire Bonder Pick and Place Laser Probe Station Wafer Saw

45 Human Technology Interaction Lab Metabolic Analyzer Motion Tracker Stress Photonics

46 Cryogenic Storage Cell Culture Core Biosafety Cabinet rtpcr Incubator

47 User Study Space Controlled User Study Space Sleep Monitor Space Exercise Measurement Instrumented Living Space

48 UMass Excellence in R2R Manufacturing An established center of excellence in nanomanufacturing Faculty Include: James Watkins Kenneth Carter Jonathan Rothstein Center for Hierarchical Manufacturing $36M through 2016 J. Watkins, Director Second Skin Military Fabric $11M total, $2M at UMass 14-member Industry Advisory Board for R2R R2R Pre-competitive Research Consortium 1:1 Industry Research Programs Founding Member DOD NanoBio Manufacturing Consortium Extensive Industry Partnerships

49 Cross-Industry Investment in R2R/Printed Electronics at UMass Amherst Microfluidics Sensor arrays MEMS Flexible displays Energy harvesting/storage Antennas Logic circuits Why This Matters for Health Monitoring Each of these applications can be used in personalized health monitoring devices Mass produced components at low cost Flexible form factor Devices can be made in the USA Model of current UMA roll-toroll research system