Institut Català de Nanociència i Nanotecnologia. Pablo Ordejón - Director

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1 Institut Català de Nanociència i Nanotecnologia Pablo Ordejón - Director

2 ICN2: Contextual Background Move towards a knowledge-based economy (Lisbon [2000] and Barcelona [2003] EU agreements for 2020) Improve economic competitiveness and social welfare CERCA centres: Non-profit foundations created by the Catalan Government since early 2000 s to promote R&D excellence ICREA programme to attract talent: 240 professorships (41% in CERCA institutes; ~10% of applicants selected; 48% foreign nationality; 62% recruited from abroad) Largest public Science institution in Spain; 3 rd largest in Europe Basic and Applied R&D; Technology Transfer; Sci/Tech Consulting; Training; Dissemination of Scientific Culture, etc. Physical, Natural, Life and Social Sciences; Humanities; and Food/Agriculture Major research infrastructure: laboratories, technical facilities, libraries, databases and public repositories

3 ICN2 Introduction Mission: To lead the advance of N&N by generating new fundamental knowledge, concepts and ideas. To facilitate the adoption and integration of nanotechnologies in society and industry. Core activities: Excellence research in Nanoscience Pushing the frontiers of Nanotechnology Advanced Training Technology Transfer Science and Society - Public Outreach

4 ICN2: In numbers Annual Budget: ~10 M Sources: Patrons: 50%, Competitive Funding: 45%, Tech Transfer (contracts, IP): 5% Total staff: ~ 200 Demographics: 45% foreigners, 44% female, 70% are 35 or younger, Researchers: 170 (130 staff + 40 visiting), working language is English Research Groups: 17 Technical Divisions: 3 Distinguished Awards: 6 ERC (3 current + 3 past); Severo Ochoa Award Scientific Output: ~170 indexed publications/year (average IF~6.5) ICN2 is in the top-ten of all Spanish R&D centres in all measures of excellence, 3rd place in Excellence Rate (% of papers among the 10% most cited in their fields)* *SCIMAGO Institutions Ranking 2013 Total laboratory space: ~2,000 m 2 Key facilities: electron microscopes (SEM, S/TEM, TEM, STM, AFM), R2R NIL; FIB; XPS; Nanomoke, wet chemistry labs, access to clean rooms (UAB and CNM)

5 Courtesy del Prof. Helmut Dosch Max Planck Institute for Metal Research Stuttgart (Alemania)

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7 Nanoscience and Nanotechnology Exploring and exploiting the new phenomena that arise from the behaviour of matter at the nanoscale (1-100 nm) Devices from Nanostructures Nanofabrication Integration - nano-micro-macro Design / function Manipulation at the atomic and molecular scale (Top-down and Bottom-up) Scanning Probe Microscopies Thin Film Technologies (PLD, MBE, CVD...) Nanolithography Self-Assembly Characterization Chemical of Nanostructures synthesis of nano-objects Advanced Electronic Nanoscopy Scanning Probe Microscopies and Spectroscopies Chemical Analysis Spectroscopies Fundamental Physical Phenomena Electronic and other excitations (electronics, Nano-materials spintronics, with new phononics, properties photonics,...) Quantum confinement Biosensing Non-scalable behaviour Acting on biological processes: Drug Delivery Toxicity / Safety / Environment Energy storage Catalysis Optical nano-materials

8 ICN2 Research Lines: 17 Research Groups

9 ICN2 Services and Technical Divisions General Scientific Services Instrumentation for Physical and Chemical Characterization Nanoscience Instrument Development Design and development of advanced state-of-the-art instruments for nanoscience and nanotechnology. Electron Microscopy Scientific and technical support to the research lines of ICN2 and neighboring research centres Nanofabrication and Flexible Printing Platform Design and development of nanofabrication methods for nanoscience and nanotechnology research and applications. Nanomaterials Growth Facility to grow nanostructured materials by means of several growth techniques (PLD, CVD,...), and characterize them (XDR, PES,...)

10 ICN2: Frontier research Biosensing and Bioelectronics Chemical Synthesis of Nanostructures Materials at the Nanoscale Microscopy (AFM, SEM, TEM, STM, etc.) Nanoelectronics Nanofabrication (FIB) & Nanolithography Nanomagnetism Phononics and Photonics Theory and Simulation Spectroscopy (Raman, XRD, XPS, etc.) Spintronics Surface Properties

11 ICN2: Materials Biomolecules (DNA, RNA, proteins, etc.) Carbon nanotubes Graphene Ferroics (magnetic, electric) Inorganic nanoparticles Inorganic thin films Metal-organic frameworks Organic polymers and O/I hybrids Semiconductors Thermoelectric materials Topological insulators

12 ICN2: Devices and end-products Analytical instruments Biosensors Drugs and drug-delivery vectors Medical diagnostics Nanoparticles for Health and Environment Flexible and printed electronics Memory devices Metamaterials and smart materials Smart City devices Energy harvesting, conversion and storage Paints and coatings Photochromes

13 Nanodevices for Societal Challenges ICN2 will use scientific knowledge generated in-house to develop new, disruptive solutions for the design, fabrication and integration of devices in three Core Areas: Energy Life ICT

14 Nanodevices for Societal Challenges ICN2 will use scientific knowledge generated in-house to develop new, disruptive solutions for the design, fabrication and integration of devices in three Core Areas: Energy: fuel cells, thermoelectrics, photovoltaics, batteries, supercapacitors, energy harvesting, thermal management, etc. Life Sciences: biosensors, drug delivery, theranostics, environment, etc. ICT: new approaches for memory and logic devices, waveguides, LEDs, lasers, etc.

15 Nanodevices for Societal Challenges Progress in the three Core Areas will be supported by four Transversal Platforms: Theory & Simulation Nanomaterials Growth Nanofabrication Characterization & Metrology Energy Life ICT

16 Collaboration with Industry

17 ACADEMIA-INDUSTRY: our collaboration model OPEN INNOVATION: TWO-WAY COLLABORATION Technology Transfer ACADEMIA INDUSTRY PRODUCT WORKING WITH INDUSTRY

18 Chemotherapy and Nephrotoxicity Nephrotoxicity is the main limitation of current chemotherapy with cisplatin Glomerular Filtration

19 Cisplatin - Au NPs (ICREA Prof. V. Puntes) Aurocis

20 Cisplatin - Au NPs (ICREA Prof. V. Puntes) - Aurocis does not pass through the glomerular filter, which prevents kidney damage - Cisplatin - NP link is ph sensitive: only breaks after cell uptake; Thus it is inactive while circulating through the organism, avoiding unspecific release. It also targets preferencially tumor cells, as they have a more acid character than normal cells. - Free Cisplatin binds to albumina, lending it inactive. Binding to gold NPs prevents this.

21 Cisplatin - Au NPs (ICREA Prof. V. Puntes) Spin-off of ICN2 (V. Puntes) Novel cancer treatments using AuNPs as drug delivery vector A specific drug-np complex (based on Cisplatin) has been identified and is in the stage of animal testing If tests are successful, production and commercialization will be done by Ferrer (pharma company)

22 Photoprotective Coatings: Photochromes Requirements: Light induced conversion from colorless to colored state T-type photochromes: transparent colored Fast color darkening and fading kinetics Limitations in solid matrices: steric effects provoke slow switching

23 Encapsulating Photochromes (Daniel Ruiz-Molina) Microcapsules: Interfacial polymerization of oil-in-water emulsions

24 Encapsulating Photochromes Ophthalmic lenses Protective lenses / screens Smart Windows - Greenhouses Clothing

25 Biocides (ICREA Prof. Daniel Maspoch) Markets demand Biocides of long-life antimicrobial activity. 100 disinfectant companies in Europe with employees (2011). Disinfectant production achieved a turnover of 3 billion in EtOH H 2 O 2 Surfaces: Disinfectants Skin: Antiseptics Nosocomial infection (surgical wounds, urinary and respiratory tract). Mayor causes of death and increase morbidity in hospitalized patients. Suffered by 8.7% of hospital patients. Cost: 5-10 Bi$/year, death/year (in the US alone).

26 Encapsulating Biocides (ICREA Prof. Daniel Maspoch) ClO 2 Oi l Water ClO 2 /O/W Double emulsion technology

27 Encapsulating Fragrances (ICREA Prof. D. Maspoch) Micro and Nano-encapsulation of fragrances for softeners Licensing Agreement: Royalties for ICN2 in sales of products Expected ICN2 earnings: 0.1 M /year A plant is in production, and commercial products are already available. First royalties received in 2013

28 Encapsulating Biocides (ICREA Prof. D. Maspoch) Micro and Nano-encapsulation for fungicidal paints Licensing Agreement: Royalties for ICN2 in sales of products Product (Fungipol CP) already commercialized by Chemipol

29 Graphene at ICN2: The whole innovation value chain Comunitat Emergent Grafè

30 National Center Microelectronics Materials Science Institute UAB MATGAS ICN2 ALBA Synchrotron A cluster with nearly 750 scientists and technicians in the areas of Materials, Micro and Nanotechnologies

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35 THANK YOU Pablo Ordejón Director Jordi Reverter Technology Transfer / Institut Català de Nanociència i Nanotecnologia (ICN2) ICN2 Building, Campus UAB Bellaterra, Barcelona (SPAIN)